Core-shell particle including signal-generating substance enclosed therein and process for producing the same
US6881484B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | May 30, 2001 |
| Grant date | Apr 19, 2005 |
| Priority date | — |
| Expiry date | May 30, 2021 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2998
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A core-shell particle including a signal-generating substance therein, wherein the core-shell particle consists of (1) a core portion substantially made of a water-insoluble polymer compound; and (2) a shell portion substantially made of a water-soluble polymer compound having a reactive functional group, and covering a surface of the core portion in the manner of bristles of a brush; and the core portion and the shell portion are, as a whole, a block copolymer of a water-insoluble polymer and a water-soluble polymer, characterized in that the signal-generating substance is included in the core portion, is disclosed, and a process for producing the same is also disclosed.The core-shell particle including a signal-generating substance therein is useful as a labeling substance in which neither radioisotopes having handling restrictions nor unstable enzymes are required, a high sensitivity superior to fluorescent substances is achieved, and nonspecific absorption does not occur.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.