Pharmaceutical agents

US6881740B1 · kind B1 · utility

Assignee

• MONASH UNIVERSITY · AU

Inventors

• Bevyn Jarrott · Melbourne, AU
• Phillip Mark Beart · Ivanhoe, AU
• William Roy Jackson · Melbourne, AU
• Alan D. Robertson · Hornsby, AU
• Maree Patricia Collis · Melbourne, AU
• Alexandra Papanikos · Ekeren, BE

Key dates

• Filing date: Jul 8, 1999
• Grant date: Apr 19, 2005
• Expiry date: Jul 8, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to compounds to formula (1) wherein B is optionally substituted aryl; R1 and R2 are the same or different and are independently selected from hydrogen or C1-3 alkyl; n is 1 or 2, preferably n is 1; m is 0 or 1; R3 is hydrogen or acyl, R4 and R5 are the same or different and are independently selected from amino, alkylamino, dialkylamino, arylamino and C2-C4 cycloalkylamino; X and Y are independently selected from C, H or N provided at least one of X and Y is N; and salts thereof, solvates thereof, pharmaceutically acceptable derivatives thereof, prodrugs thereof, tautomers thereof and/or isomers thereof, and processes for their reparation and methods of treatment, pharmaceutical formulations and uses involving them.