Tricyclic diterpene derivatives
US6881857B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Feb 4, 2002 |
| Grant date | Apr 19, 2005 |
| Priority date | — |
| Expiry date | Jun 27, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/26
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein are novel tricyclic diterpene compounds. These compounds, including their prodrug esters and acid-addition salts, are useful as Interleukin-1 and Tumor Necrosis Factor-α modulators, and thus are useful in the treatment of various diseases.Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of the novel compounds that are useful as anti-inflammatory analgesics, in treating immune disorders, as anti-cancer and anti-tumor agents, and in the treatment of cardiovascular disease, skin redness, and viral infection. Completely synthetic and semi-synthetic methods of making the compounds and their analogs are also disclosed, as are methods of using these synthetic and semi-synthetic compounds in the treatment of the above-listed disease states.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.