Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality
US6881860B2 · kind B2 · utility
13Cited by
9References
33Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 11, 2001 |
| Grant date | Apr 19, 2005 |
| Priority date | — |
| Expiry date | Sep 18, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/044
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
It has been discovered that certain selected ethers of probucol, and their pharmaceutically acceptable salts or prodrugs, are useful for increasing circulating HDL cholesterol. These compounds may also improve HDL functionality by (a) increasing clearance of cholesteryl esters, (b) increasing HDL-particle affinity for hepatic cell surface receptors or (c) increasing the half life of apoAI-HDL.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.