Method for preparing submicron particle suspensions
US6884436B2 · kind B2 · utility
45Cited by
157References
97Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 12, 2001 |
| Grant date | Apr 26, 2005 |
| Priority date | — |
| Expiry date | Dec 12, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/1688
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a method for preparing a suspension of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first organic solvent than in a second solvent which is aqueous. The process includes the steps of: (i) dissolving a first quantity of the pharmaceutically-active compound in the water-miscible first organic solvent to form a first solution; (ii) mixing the first solution with the second solvent to precipitate the pharmaceutically-active compound; and (iii) seeding the first solution or the second solvent or the pre-suspension.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.