Combination preparation for contraception based on natural estrogens

US6884793B2 · kind B2 · utility

Assignee

• Jenapharm GmbH & Co. KG · DE

Inventors

• Michael Dittgen · Apolda, DE
• Sabine Fricke · Jena, DE
• Herbert Hoffmann · Jena, DE
• Claudia Moore · Jena, DE
• Michael Oettel · Jena, DE
• Monika Ostertag · Göttingen, DE

Key dates

• Filing date: Sep 12, 2001
• Grant date: Apr 26, 2005
• Expiry date: Sep 12, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P15/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The combination preparation for contraception includes from 2 to 4 first stage daily dosage portions each including an effective amount of at least one natural estrogen as sole active ingredient, from 16 to 22 second stage daily dosage portions each including an effective amount of a combination of at least one natural estrogen and at least one natural or synthetic gestogen as active ingredient; from 2 to 4 third stage daily dosage portions each including an effective amount of at least one natural estrogen as sole active ingredient; and from 2 to 4 final stage daily dosage portions containing a pharmaceutically acceptable placebo. The estrogen may be estradiol, an estradiol compound that is metabolized to estradiol when taken into the body, a conjugated equine estrogen or a phytoestrogen. The natural or synthetic gestogen can be natural progesterone or a synthetic gestogens, such as medroxyprogesterone acetate.