Bicyclic lactam derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE)

US6884806B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Carl P. Decicco · New Hope, US
• Ying Song · Hockessin, US
• Jingwu Duan · Yardley, US
• Matthew E. Voss · Singapore, SG

Key dates

• Filing date: Oct 16, 2002
• Grant date: Apr 26, 2005
• Expiry date: Nov 20, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present application describes novel bicyclic lactam derivatives of formula I: or pharmaceutically acceptable salt forms thereof, wherein A, B, C, D, R1, and R2 are defined in the present specification, which are useful as metalloprotease, TNF-α, and/or aggrecanase inhibitors.