Antimicrobial dihydrothiazine and dihydrothiopyran oxazolidinones

US6884813B2 · kind B2 · utility

Assignee

• Pharmacia & Upjohn Company LLC · US

Inventors

• Mikhail Gordeev · Castro Valley, US
• Adam Renslo · Oakland, US
• Gary W. Luehr · Foster City, US
• Stuart Lam · San Francisco, US
• Neil Westlund · Groton, US
• Dinesh V. Patel · Fremont, US

Key dates

• Filing date: Jan 21, 2003
• Grant date: Apr 26, 2005
• Expiry date: May 9, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein A is a structure i, ii, iii, or iv X is CR7; Y is —S(═O)n—, —S(═NR8)—, or —S(═NR8)(═O)—; Z is —NHC(═O)R1, —NHC(═S)R1, —NR-het1, —O-het1, —S-het1, or -het2; and n is independently 0, 1, or 2. The compounds of formula I are useful as antimicrobials against a number of human and veterinary pathogens.