Humanized antibodies against human 4-1BB

US6887673B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Maria Jure Kunkel · Plainsboro, US
• Subinay Ganguly · Newtown, US
• Ralph Abraham · Lawrenceville, US
• Diane Hollenbaugh · Seattle, US
• Jill Rillema · Princeton, US
• Barbara A. Thorne · Issaquah, US
• Walter W. Shuford · Redmond, US
• Robert Mittler · Decatur, US

Key dates

• Filing date: Jul 30, 2003
• Grant date: May 3, 2005
• Expiry date: Oct 15, 2023

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/105831
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A humanized antibody that binds to human 4-1BB and that allows binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating cancer in a subject comprising administering a therapeutically effective amount of the antibody to said subject.