Process for the enzymatic preparation of enantiopure 1, 3-dioxolan-4-one and 1,3-oxathiolan-5-one derivatives

US6887700B2 · kind B2 · utility

Assignee

• Consortium für elektrochemische Industrie GmbH · DE

Inventors

• Alfred Popp · Unterhaching, DE
• Jürgen Stohrer · Pullach, DE
• Hermann Petersen · Burghausen, DE
• Andrea Gilch · Moosburg an der Isar, DE
• Jodoca Rockinger-Mechlem · Gilching, DE

Key dates

• Filing date: Jan 30, 2002
• Grant date: May 3, 2005
• Expiry date: Aug 28, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P41/001
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A process is provided for preparing an enantiopure 1,3-dioxolan-4-one or 1,3-oxathiolan-5-one derivative, which includes bringing a mixture containing enantiomeric 1,3-dioxolan-4-one or 1,3-oxathiolan-5-one derivatives and an enzyme with hydrolytic activity into contact in the presence of a nucleophile. Cleaving a dioxolanone/oxathiolanone ring of one enantiomer occurs by the enzyme with hydrolytic activity and, after the cleavage of one enantiomer has taken place, the uncleaved enantiomer of the 1,3-dioxolan-4-one or 1,3-oxathiolan-5-one derivative is isolated.