Methods and compositions to lower plasma cholesterol levels
US6887712B1 · kind B1 · utility
29Cited by
17References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 9, 1999 |
| Grant date | May 3, 2005 |
| Priority date | — |
| Expiry date | Nov 9, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method is disclosed for determining whether a compound binds to a lipoprotein such as LDL or VLDL in a manner which will lower plasma cholesterol. The method provided includes assessing the ability of the compound to form a complex with the lipoprotein, and then determining whether the newly formed complex causes a change in the structure of apoB-100 that results in increased binding affinity to an LDL receptor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.