Compounds for intracellular delivery of therapeutic moieties to nerve cells
US6887861B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 6, 2000 |
| Grant date | May 3, 2005 |
| Priority date | — |
| Expiry date | Jun 18, 2021 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/21
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for improving intracellular administration of a therapeutic agent is provided comprising: contacting cells with a compound comprising a charged derivative of a therapeutic agent having a therapeutic activity, the charged derivative being conjugated to a protein having a biological activity of being transported across a cell membrane into a cell; and having the cell transport the compound into the cell where the cell metabolizes at least a portion of the compound to form a charged metabolite product that possesses the therapeutic activity of the therapeutic agent, the charged metabolite product being less prone to being transported across the cell membrane out of the cell relative to the compound and less prone to being transported across the cell membrane out of the cell relative to the therapeutic agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.