Antigens derived from filaggrin and their use for diagnosing rheumatoid polyarthritis
US6890720B1 · kind B1 · utility
11Cited by
1References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 1, 1997 |
| Grant date | May 10, 2005 |
| Priority date | — |
| Expiry date | Sep 1, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/4713
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention concerns an artificial antigen specifically identified by the anti-filaggrin autoantibodies present in the serum of patients suffering from rheumatoid polyarthritis, and consisting of one polypeptide comprising all or part of the sequence of one filaggrin unit or of a related molecule, in which an arginine radical has been substituted by a citrulline radical. The invention also concerns the use of this antigen for diagnosing rheumatoid polyarthritis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.