Methods for producing proteins in cultured cells
US6890736B1 · kind B1 · utility
57Cited by
4References
29Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 16, 2003 |
| Grant date | May 10, 2005 |
| Priority date | — |
| Expiry date | Sep 16, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P21/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides a method for increasing production of a protein by cultured mammalian cells comprising adding a DNA demethylating agent, for example a cytidine analogue, to the mammalian cell culture. The cytidine analogue can be 5-aza-2′-deoxycytidine (also called decitabine) or 5-bromo-2′-deoxycytidine-5′-monophosphate, among many other possible cytidine analogues.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.