Modified ribozymes

US6890908B1 · kind B1 · utility

Assignee

• Max-Planck-Gesellschaft zur Föderung der Wissenschaften e.V. · US

Inventors

• Fritz Eckstein · Göttingen, DE
• Wolfgang Pieken · Boulder, US
• Fritz Benseler · Oettingen, DE
• David B. Olsen · Johnstown, US
• David M. Williams · Cambridge, GB
• Olaf Heidenreich · Bingen, DE

Key dates

• Filing date: Sep 24, 1997
• Grant date: May 10, 2005
• Expiry date: Sep 24, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/322
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention refers to an RNA molecule with catalytic activity comprising at least one modified nucleoside, wherein the hydroxy group at the 2′-position of the ribose sugar is replaced by a modifier group, selected from halo, sulfhydryl, azido, amino, monosubstituted amino and disubstituted amino groups, a process for the preparation of modified RNA molecules and the use of modified RNA molecules as therapeutic agents and biocatalysts.