Quaternary ammonium compounds

US6890920B2 · kind B2 · utility

Assignee

• Pharmacia & Upjohn Company LLC · US

Inventors

• Ivan Richards · Kalamazoo, US
• Sue Cammarata · Portage, US
• Craig D. Wegner · New Milford, US
• Michael Hawley · Davis, US
• Mark P. Warchol · Kalamazoo, US
• Mark Kontny · Libertyville, US
• Walter Morozowich · Kalamazoo, US
• Karen Kolbasa · Manistique, US
• Malcolm W. Moon · Kalamazoo, US
• Dominique Bonafoux · Saint Louis, US
• Sergey Gregory Wolfson · Chesterfield, US
• Patrick J. Lennon · Webster Groves, US

Key dates

• Filing date: Oct 25, 2002
• Grant date: May 10, 2005
• Expiry date: Dec 5, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C237/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel quaternary ammonium compounds of the formula and any stereoisomers thereof, wherein R1, R2 and R3 independently represent C1-C6 alkyl, optionally substituted with phenyl or hydroxyl, or both, and wherein any two of R1, R2 and R3 may form a ring together with the quaternary ammonium nitrogen; R4 represents —H, —CH3, or —CO—R4-1, wherein R4-1 represents —(C1-C4 alkyl), —(C1-C4 alkoxy), or —NR4-2R4-3, wherein R4-2 and R4-3 independently represent —H or —(C1-C4 alkyl); R5, R6 and R7 independently represent —H, —OCH3, —OH, —CONH2, —SO2NH2, —F, —Cl, —Br, —I, —CF3, or —(C1-C4 alkyl), optionally substituted with one or two —OH, —(C1-C4 alkoxy), —COOH, or —CO—O—(C1-C3 alkyl); and X− represents an anion of a pharmaceutically acceptable acid, the compounds for use as medicaments, use of the compounds for the manufacture of specific medicaments, and pharmaceutical compositions comprising the compounds. The present invention also concerns a method of treatment involving administration of the compounds.