Fibrinogen bandages and arterial bleeding models and methods of making and using thereof

US6891077B2 · kind B2 · utility

Assignee

• The United States of America as represented by the Secretary of the Army · US

Inventors

• Stephen Rothwell · Columbia, US
• Chitra Krishnamurti · Potomac, US
• Thomas J. Reid · Rockville, US

Key dates

• Filing date: Jul 25, 2002
• Grant date: May 10, 2005
• Expiry date: Jan 7, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2400/04
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Disclosed herein are wound dressings comprising fibrinogen and at least one procoagulant such as propyl gallate in a therapeutic amount. Also disclosed are methods of treating wounds, increasing an amount of or rate of coagulation of blood from a wound, increasing an amount of or rate of clot formation over a wound, increasing blood platelet counts, activating a coagulation system, increasing the plasma concentration of fibrinogen, and decreasing the activated partial thromboplastin time. Also disclosed are an arterial bleeding model and methods of studying arterial bleeding.