Compositions for TRP-M8 binding and radioreceptor methods therewith
US6893626B2 · kind B2 · utility
4Cited by
6References
7Claims
0Family size
Inventor
Key dates
| Filing date | Feb 18, 2003 |
| Grant date | May 17, 2005 |
| Priority date | — |
| Expiry date | Jul 20, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/05
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
One embodiment of the invention is a composition that comprises a radioactive 32P or 33P phosphine oxide molecule. The said composition is designed to bind to the transient potential receptor-M8 (TRP-M8) receptor of cells. The radioactive 32P or 33P phosphine oxide ligand may be used for radioreceptor binding studies and for diagnostic studies of cancerous tissues. The TRP-M8 receptor is selectively expressed in malignant tissues such as prostate cancer cells. Affinity of the 32P or 33P phosphine oxide ligand for the TRP-M8 receptor confers selectively and specificity in delivering lethal radiation to the diseased cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.