Process for surface modifying substrates and modified substrates resulting therefrom

US6893685B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Yongxing Qiu · Duluth, US
• Lynn Cook Winterton · Roswell, US
• John Martin Lally · Lilburn, US
• Paul Pasic · Melbourne, AU
• Hans Griesser · Cockatoo, AU
• Peter Kambouris · Melbourne, AU
• Peter Chabrecek · Clayton, AU

Key dates

• Filing date: Aug 24, 2001
• Grant date: May 17, 2005
• Expiry date: Feb 3, 2023

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/31928
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

The invention relates to a process for coating a material surface, comprising the steps of: (a) applying to the material surface a tie layer comprising a polyionic material; (b) covalently binding a bifunctional compound comprising an ethylenically unsaturated double b3nd to the tie layer; and (c) graft polymerizing a hydrophilic monomer onto the compound comprising the ethylenically unsaturated double bond. The coated articles that are obtainable by the process of the invention have desirable characteristics regarding adherences to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.