Influenza sensor

US6893814B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Basil I. Swanson · Los Alamos, US
• Xuedong Song · Alpharetta, US
• Clifford J. Unkefer · Los Alamos, US
• Louis A. Silks · Los Alamos, US
• Jurgen Schmidt · Los Alamos, US

Key dates

• Filing date: Aug 28, 2003
• Grant date: May 17, 2005
• Expiry date: Aug 28, 2023

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/200833
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A sensor for the detection of tetrameric multivalent neuraminidase within a sample is disclosed, where a positive detection indicates the presence of a target virus within the sample. Also disclosed is a trifunctional composition of matter including a trifunctional linker moiety with groups bonded thereto including (a) an alkyl chain adapted for attachment to a substrate, (b) a fluorescent moiety capable of generating a fluorescent signal, and (c) a recognition moiety having a spacer group of a defined length thereon, the recognition moiety capable of binding with tetrameric multivalent neuraminidase.