Method for producing trifluoro-3(r)-hydroxybutyric acid derivatives
US6893861B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 18, 1999 |
| Grant date | May 17, 2005 |
| Priority date | — |
| Expiry date | Feb 18, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P13/02
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to a biotechnological method for producing trifluoro-3(R)-hydroxybutyric acid derivatives of the general formula (I), where R1 represents —OR2, where R2 is hydrogen, C1-10 alkyl, C1-10 alkenyl, C3-8 cy-cloalkyl, aryl, alkoxyalkyl or alkoxyalkoxyalkyl; —NR3R4, where R3 and R4 are the same or different and represent hydrogen, C1-10 alkyl, C1-10 alkenyl, C3-8 cycloalkyl or aryl; or —SR5, where R5 represents hydrogen, C1-10 alkyl, C1-10 alkenyl, aryl or C3-8 cycloalkyl, based on a trifluoroacetoacetic acid derivative of the general formula (II), where R1 has the meaning given above, by means of micro-organisms which are able to reduce a carbonyl function or by means of a cell-free enzyme extract of said micro-organisms.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.