Growth factor modified protein matrices for tissue engineering
US6894022B1 · kind B1 · utility
11Cited by
16References
6Claims
0Family size
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Key dates
| Filing date | May 1, 2000 |
| Grant date | May 17, 2005 |
| Priority date | — |
| Expiry date | May 1, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/475
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Proteins are incorporated into protein or polysaccharide matrices for use in tissue repair, regeneration and/or remodeling, and/or drug delivery. The proteins can be incorporated so that they are released by degradation of the matrix, enzymatic action, and/or diffusion. In one embodiment, a fusion protein, which contains a crosslinking region, such as a factor XIIIa substrate, and a native protein sequence, such as a bioactive factor, is constructed. Degradable linkages may be included between the crosslinking region and the bioactive factor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.