Compositions and methods for the therapy and diagnosis of prostate cancer

US6894146B1 · kind B1 · utility

Assignee

• CORIXA CORPORATION · US

Inventors

• Jiangchun Xu · Bellevue, US
• Davin C. Dillon · Issaquah, US
• Jennifer Mitcham · Redmond, US
• Susan Harlocker · Foster City, US
• Yuqiu Jiang · Kent, US
• Michael D. Kalos · Philadelphia, US
• Gary Fanger · Mill Creek, US
• Marc Retter · Carnation, US
• John Stolk · Bothell, US
• Craig Day · Seattle, US
• Thomas S. Vedvick · Federal Way, US
• Darrick Carter · Seattle, US
• Samuel X. Li · Redmond, US
• Aijun Wang · Davis, US
• Yasir Skeiky · Bellevue, US
• William T. Hepler · Seattle, US
• Robert A. Henderson · Seattle, US

Key dates

• Filing date: Sep 6, 2000
• Grant date: May 17, 2005
• Expiry date: Sep 6, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/16022
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.