Methods of producing phosphitylated compounds

US6894158B2 · kind B2 · utility

Assignee

• HONEYWELL INTERNATIONAL INC. · US

Inventors

• Christian Werner · Hannover, DE
• Frank Nerenz · Seelze, DE
• Andreas Kanschik-Conradsen · Garbsen, DE
• Kalakota S. Reddy · Midland, US

Key dates

• Filing date: Feb 24, 2003
• Grant date: May 17, 2005
• Expiry date: Feb 24, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Provided are methods of producing phosphitylated compounds, including 3′-O-phosphoramidites, comprising the step of reacting a hydroxyl-containing compound with a phosphitylating agent in the presence of a phosphitylation activator selected from the group consisting of: (1) acid-base complexes derived from an amine base of Formula I wherein R, R1, and R2 are independently C1-C10 alkyl, C3-C10 cycloalkyl, C6-C10 aryl, C7-C10 aralkyl, C1-C10 heteroalkyl, or C1-C10 heteroaryl, wherein any two adjacent R, R1, and R2 may be connected to form a heterocyclic ring; (2) acid-base complexes derived from a diazabicyclo amine base; and (3) combinations of two or more thereof.