Process for preparing 2-cyano-3-hydroxy-N-(phenyl)but-2-enamides

US6894184B2 · kind B2 · utility

Assignee

• Aventis Pharma Deutschland GmbH · DE

Inventors

• Jochen Hachtel · Frankfurt, DE
• Bernd Neises · Offenburg, DE
• Wilfried Schwab · Altentreptow, DE
• Roland Utz · Messel, DE
• Martin Zahn · Hofheim, DE

Key dates

• Filing date: Mar 17, 2004
• Grant date: May 17, 2005
• Expiry date: Apr 26, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C253/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process is described for producing 2-cyano-3-hydroxy-N-(phenyl)but-2-enamide, in which a phenyl-substituted 2-cyano-N-(phenyl)acetamide is reacted in the presence of a base, acetic anhydride and at least one solvent, and the resultant 2-cyano-3-hydroxy-N-(phenyl-derivative)but-2-enamide is crystallized by acidification.