Method for ultrasound triggered drug delivery using hollow microbubbles with controlled fragility
US6896659B2 · kind B2 · utility
65Cited by
14References
25Claims
0Family size
Assignee
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Key dates
| Filing date | Oct 22, 2001 |
| Grant date | May 24, 2005 |
| Priority date | — |
| Expiry date | May 30, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B5/4839
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method is provided for site specific delivering therapeutic or diagnostic agents to a region in a fluid-filled cavity, vessel or tissue using an agent-loaded microbubble population. The population has controlled fragility characterized by a uniform wall thickness to diameter ratio which defines the discrete threshold intensity value of ultrasonic power where microbubble rupture occurs in the population. The location of the microbubble population may be monitored by ultrasound to determine its presence at the region prior to application of the ultrasonic power to rupture to microbubbles.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.