Cell-specific and/or tumor-specific promoter retargeting of herpes γ 34.5 gene expression
US6897057B1 · kind B1 · utility
5Cited by
7References
25Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 31, 2000 |
| Grant date | May 24, 2005 |
| Priority date | — |
| Expiry date | Nov 3, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to herpes viral mutants and methods of using these viral mutants for selectively targeting tumor cells or other populations of target cells. The viral mutants of the invention are capable of selective targeting due to the use of tumor-specific and/or cell-specific promoters to drive expression of the herpes γ34.5 gene.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.