Oligonucleotide delivery systems for camptothecins

US6897200B1 · kind B1 · utility

Assignee

• University of Kentucky Research Foundation · US

Inventors

• Thomas Burke · Lexington, US
• Ayhan Demir · Neunkirchen, DE
• Ashok Chavan · Bloomington, US
• Danzhou Yang · Lexington, US

Key dates

• Filing date: Oct 14, 1998
• Grant date: May 24, 2005
• Expiry date: Oct 14, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/127
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Camptothecin drugs are stabilized in their antitumor active lactone form by complexation with an oligonucleotide including RNA or catalytic RNA. The oligonucleotide-camptothecin drug complex may be incorporated within a macromolecular assembly including both viral and non-viral oligonucleotide vectors. The invention allows combination gene and camptothecin drug therapy.