Prodrugs of proton pump inhibitors

US6897227B2 · kind B2 · utility

Assignees

• Winston Pharmaceuticals, Inc. · US
• The United States of America as represented by the Department of Veteran Affairs · US
• The Regents of the University of California · US

Inventors

• Michael E. Garst · Newport Beach, US
• George Sachs · Calabasas, US
• Jai Shin · Brentwood, US

Key dates

• Filing date: Jul 15, 2003
• Grant date: May 24, 2005
• Expiry date: Jul 18, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Prodrugs of proton pump inhibitors of Formulas 1 through 4, where the symbols are as defined in the specification, and the R group includes at least one acidic group or its pharmaceutically acceptable salt, have improved aqueous solubility and bioavailability.