Patent · US Expired

Process for the preparation of 11-oxaprostaglandins and intermediates therein

US6897324B2 · kind B2 · utility

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19Claims
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Assignee

Inventors

Key dates

Filing dateMay 16, 2001
Grant dateMay 24, 2005
Priority date—
Expiry dateApr 28, 2022

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07F7/188
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

For the preparation of an 11-oxaprostaglandin such as [2R,(1E,3R),3S,(4Z),4R)]-7-{tetrahydro-2-[4-(3-chlorophenoxy)-3-hydroxy-1-butenyl]-4-hydroxy-3-furanyl}-4-heptenoic acid and its ester derivatives, a novel process uses a novel enantiomerically enriched compound for formula (1) wherein the bond between carbon atoms y and z is either a single or double bond; R1 is selected from vinyl, trialkylsilylethynyl, a formyl group protected as an acetal, or a protected hydroxymethyl group; R2 is C1-5 alkyl, optionally substituted at the terminus with an aryloxy or alkoxy group; and R3-R6 are independently selected from C1-6 alkyl and C6-10 aryl

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.