Osteoinduction of cortical bone allografts by coating with biopolymers seeded with recipient periosteal bone cells

US6899107B2 · kind B2 · utility

Assignee

• Cambridge Scientific, Inc. · US

Inventors

• Kai-Uwe Lewandrowski · Brookline, US
• Shrikar Bondre · Monmouth Junction, US
• Debra J. Trantolo · Princeton, US
• Maurice V. Cattaneo · Quincy, US
• Joseph D. Gresser · Brookline, US
• Donald L. Wise · Belmont, US

Key dates

• Filing date: Dec 27, 2002
• Grant date: May 31, 2005
• Expiry date: Feb 16, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/02
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A method by which immune responses to cortical bone grafts and other substrates (e.g., cement, IPN, etc.) can be minimized and at the same time graft osteoinductive potential can be improved, and improved graft substrate materials are disclosed. The method of the invention provides new types of bone grafts that incorporate into host bone more thoroughly and more rapidly, eliminating long-term complications, such as fracture, non-union, infection, and rejection. In the method of the invention, bone grafts or other substrates are modified to have an osteoinductive surface modification that the recipient's body will accept as its own tissue type and therefore will not reject or otherwise cause to fail. The osteoinductive surface modification comprises a biopolymer matrix coating that is seeded with periosteal cells that have been previously harvested either from the graft recipient or from an allogenic or xenogenic donor source.