Transdermal therapeutic system containing hormones and crystallization inhibitors

US6899894B1 · kind B1 · utility

Assignee

• LTS Lohmann Therapie-Systeme AG · DE

Inventors

• Robert-Peter Klein · Neuwied, DE
• Reinhold Meconi · Neuwied, DE
• Walter Muller · Neuwied, DE

Key dates

• Filing date: Jun 8, 1999
• Grant date: May 31, 2005
• Expiry date: Jun 8, 2019

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/939
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A transdermal therapeutic system in plaster form for controlled release of oestradiol in combination with norethisterone acetate, comprising a backing layer, a reservoir supersaturated with active ingredients which is attached to said backing layer and prepared using polyacrylate pressure-sensitive adhesives and crystallization inhibitors, and a detachable protective layer, is characterized in that the crystallization inhibitor is an amino-containing polymer.