Substituted lactams as inhibitors of Aβ protein production
US6900199B2 · kind B2 · utility
13Cited by
30References
39Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 14, 2003 |
| Grant date | May 31, 2005 |
| Priority date | — |
| Expiry date | Nov 2, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D403/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to novel lactams of Formula (I): having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.