Cycloalkyl alkanoic acids as integrin receptor antagonists

US6900232B2 · kind B2 · utility

Assignee

• Pharmacia Corporation · SE

Inventors

• Ish Khanna · Vernon Hills, US
• Michael Clare · Skokie, US
• Alan F. Gasiecki · Vernon Hills, US
• Thomas E. Rogers · Ballwin, US
• Barbara Chen · Braintree, US
• Mark Russell · Skokie, US
• Hwang-Fun Lu · Ballwin, US

Key dates

• Filing date: Jun 15, 2001
• Grant date: May 31, 2005
• Expiry date: Jun 15, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a class of compounds represented by the Formula I Wherein A1 is a pyridinyl of the formula optionally substituted by one or more Rk selected from the group consisting of hydroxy, alkyl, alkoxy, alkoxyalkyl, thioalkyl, haloalkyl, cyano, amino alkylamino, halogen, acylamino, sulfonamide and —COR; and R is hydroxy, alkoxy, alkyl or amino; and pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αvβ3 and/or αvβ5 integrin.