Cost effective method for selective methylation of erythromycin A derivatives

US6900296B2 · kind B2 · utility

Assignee

• RANBAXY LABORATORIES LIMITED · IN

Inventors

• Mohammad Salman · Barwala, IN
• Parma Chandra Ray · New Delhi, IN
• Kiran Kumar Gangakhedkar · Barwala, IN
• Harish Niranjan Lal Dorwal · Barwala, IN
• Naresh Kumar · Barwala, IN

Key dates

• Filing date: May 7, 2001
• Grant date: May 31, 2005
• Expiry date: Sep 14, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H17/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a cost effective and industrially advantageous process for the selective methylation of a hydroxy group at the 6 position of erythromycin A derivative which comprised methylating the erythromycin A derivative with a methylating agent in a mixture of toluene and a ploar aprotic solvent.