Laminates containing an active substance transdermal system

US6902741B1 · kind B1 · utility

Assignee

• Jenapharm GmbH & Co. KG · DE

Inventors

• Detlef Grawe · Kleinromstedt, DE
• Peter Hoesel · Jena, DE
• Wilfried Fischer · Holzkirchen, DE

Key dates

• Filing date: Feb 8, 2000
• Grant date: Jun 7, 2005
• Expiry date: Feb 8, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P5/24
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The transdermal system includes a sex hormone-containing adhesive matrix, which contains inclusions of a sex hormone in a hydrophilic non-crosslinked polymer in dissolved or dispersed form. The inclusions have a concentration of 20 to 90 percent by weight of the sex hormone, which is more than 50 percent by weight amorphous. The hydrophilic non-crosslinked polymer can be polyvinylpyrrolidone, methylcellulose, ethylcellulose or hydroxyethylcellulose. The adhesive matrix can be a polyisobutylene, ethylene-vinyl-acetate copolymer or a polystyrene-butadiene block copolymer.