Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix

US6902743B1 · kind B1 · utility

Assignee

• The United States of America as represented by the Secretary of the Army · US

Inventors

• Jean A. Setterstrom · Silver Spring, US
• Thomas R. Tice · York, US
• Elliot Jacob · Silver Spring, US
• Robert H. Reid · Kensington, US
• John E. Van Hamont · Clarence, US
• Edgar C. Boedecker · Crownsville, US
• Ramassubbu Jeyanthi · Columbia, US
• Phil Friden · Bedford, US
• F. Donald Roberts · Dover, US
• Charles E. McQueen · Olney, US
• Apurba Bhattacharjee · Kensington, US
• Alan Cross · Chevy Chase Section Five, US
• Jerald C. Sadoff · Washington, US
• Wendell D. Zollinger · Silver Spring, US

Key dates

• Filing date: Apr 6, 1998
• Grant date: Jun 7, 2005
• Expiry date: Apr 6, 2018

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer having a molar composition of lactide/glycolide from 90/10 to 40/60, which may contain a pharmaceutically-acceptable adjuvant, as a blend of uncapped free carboxyl end group and end-capped forms ranging to ratios from 100/0 to 1/99.