DSP-12 and DSP-13 dual-specificity phosphatases
US6902919B2 · kind B2 · utility
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Key dates
| Filing date | Feb 1, 2001 |
| Grant date | Jun 7, 2005 |
| Priority date | — |
| Expiry date | Feb 9, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/16
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatases DSP-12 and DSP-13, and polypeptide variants thereof that stimulate dephosphorylation of DSP-12 and DSP-13 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-12 and/or DSP-13 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.