Retroviral vectors, methods for their preparation and their use for gene transfer into CD4-positive cells

US6902929B1 · kind B1 · utility

Assignee

• Bundesrepublik Deutschland last Represented by the President of the Paul-Ehrlich-Instituts · DE

Inventors

• Klaus Cichutek · Langen, DE
• Jörn Stitz · Basel, CH

Key dates

• Filing date: Feb 27, 1998
• Grant date: Jun 7, 2005
• Expiry date: Feb 27, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16222
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to the production and use of retroviral vectors for cell specific gene transfer, specially to a production method of retroviral vectors containing capsid particles of murine leukemia virus (MLV) and envelope proteins of human immunodeficiency vises (HIV) or simian immunodeficiency viruses (SIV). Said vectors can be used for gene transfer in selected cell types, specially in CD4-positive mammal cells.