Helically organized silk fibroin fiber bundles for matrices in tissue engineering
US6902932B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Nov 16, 2001 |
| Grant date | Jun 7, 2005 |
| Priority date | — |
| Expiry date | Nov 16, 2021 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T442/2566
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provides the novel silk-fiber-based matrix which is seeded with pluripotent cells that proliferate and differentiate on the matrix to form a ligament or tendon ex vivo. Also disclosed is a bioengineered ligament comprising the silk-fiber-based matrix seeded with pluripotent cells that proliferate and differentiate on the matrix to form the ligament or tendon. A method for producing a ligament or tendon ex vivo comprising the novel silk-fiber-based matrix is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.