Use of phthalazine derivatives

US6903098B1 · kind B1 · utility

Assignee

• Abbott GmbH & Co. KG · DE

Inventors

• Wilfried Lubisch · Mannheim, DE
• Jens Sadowski · Schifferstadt, DE
• Michael Andreas Kock · Schifferstadt, DE
• Thomas Höger · Edingen-Neckarhausen, DE

Key dates

• Filing date: May 3, 2000
• Grant date: Jun 7, 2005
• Expiry date: May 3, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to the use of phthalazine derivatives as inhibitors of the enzyme poly(ADP-ribose) polymerase or PARP (EC 2.4.2.30), to the use as inhibitors of PARP-homologous enzymes and, in particular, these phthalazine derivatives also show a selective inhibition of PARP-homologous enzymes.