Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
US6905669B2 · kind B2 · utility
75Cited by
2References
18Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Apr 24, 2001 |
| Grant date | Jun 14, 2005 |
| Priority date | — |
| Expiry date | Apr 24, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions and methods are provided for treating diseases associated with aberrant silencing of gene expression such as cancer by reestablishing the gene expression through inhibition of DNA hypomethylation and histone deacetylase. The method comprises: administering to a patient suffering from the disease a therapeutically effective amount of a DNA methylation inhibitor such as a cysteine analog such as decitabine, in combination with an effective amount of histone deacetylase inhibitor such as hydroxamic acid, cyclic peptide, benzamide, butyrate, and depudecin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.