Patent · US Expired

Polyamide nucleic acid derivatives, and agents and processes for preparing them

US6905820B2 · kind B2 · utility

3Cited by

3References

69Claims

0Family size

Assignee

Aventis Pharma Deutschland GmbH · DE

Inventors

Eugen Uhlmann · Königstein, DE
Gerhard Breipohl · Scheinfeld, DE
David William Will · Schwalbach, DE

Key dates

Filing date	Apr 17, 2001
Grant date	Jun 14, 2005
Priority date	—
Expiry date	Apr 11, 2022

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10T436/143333
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to PNA derivatives which carry, at the C terminus, or at both the C and N termini of the PNA backbone, one or more phosphoryl radicals. The phosphoryl radicals carry, where appropriate, one or more labeling groups, groups for crosslinking, groups which promote intracellular uptake, or groups which increase the binding affinity of the PNA derivative for nucleic acids. The invention furthermore relates to a process for preparing the above-mentioned PNA derivatives and to their use as pharmaceuticals or diagnostic agents.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.