Real time measurement of cellular responses
US6905831B2 · kind B2 · utility
5Cited by
0References
27Claims
0Family size
Assignee
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Key dates
| Filing date | Aug 18, 2003 |
| Grant date | Jun 14, 2005 |
| Priority date | — |
| Expiry date | Aug 18, 2023 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/6875
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Living cells can be stably modified to emit different colors from the cytoplasm and nucleus, thus permitting analysis of the status of said cells and the effect of agents on said cells either by visual or instrumentally-aided observation. These observations may be made, if desired, in real time. In addition, rates of proliferation and drug sensitivities can be determined in vitro in real time by the use of cells modified to express a single fluorescent protein and observing fluorescence intensity as a function of time.
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