Methods for identifying compounds that inhibit ubiquitin-mediated proteolysis of iκb

US6905836B2 · kind B2 · utility

Assignee

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventors

• Yinon Ben-Neriah · Nesher, IL
• Irit Alkalay-Snir · Mazkeret Batya, IL
• Ada Hatzubai · Mevaseret Tsiyon, IL
• Etti Ben Shushan · Raanana, IL
• Matti Davis · Shetulim, IL
• Avraham Yaron · Jerusalem, IL

Key dates

• Filing date: Feb 10, 2003
• Grant date: Jun 14, 2005
• Expiry date: Feb 10, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/25
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Compounds that inhibit ubiquitin-mediated proteolysis of phosphorylated IκB by interfering, directly or indirectly, with the ability of β-TrCP/E3RS to engage in protein-protein association involving hnRNP-U, are useful as drugs for treating conditions associated with NF-κB activation. Cellular and non-cellular screening methods for identifying such compounds are based on monitoring the association/dissociation of β-TrCP/E3RS.