Guanidine mimics as factor Xa inhibitors

US6906070B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Pharma Company · US

Inventors

• Patrick Lam · Chadds Ford, US
• Charles G. Clark · Cherry Hill, US
• Celia Dominguez · Los Angeles, US
• John M. Fevig · McKeesport, US
• Qi Han · Wilmington, US
• Renhua Li · Wilmington, US
• Donald J. P. Pinto · Kennett Square, US
• James R. Pruitt · Landenberg, US
• Mimi L. Quan · Newark, US

Key dates

• Filing date: Aug 8, 2001
• Grant date: Jun 14, 2005
• Expiry date: Jun 16, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein rings D-E represent guanidine mimics, which are useful as inhibitors of factor Xa.