Anti-inflammatory peptides derived from IL-2 and analogues thereof
US6906170B1 · kind B1 · utility
10Cited by
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15Claims
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Key dates
| Filing date | Aug 19, 1999 |
| Grant date | Jun 14, 2005 |
| Priority date | — |
| Expiry date | Aug 19, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Synthetic anti-inflammatory peptides derived from the sequence of IL-2 are provided. Parent peptides of the sequences Ile-Val-Leu, Glu-Phe-Leu-Asn-Arg-Trp-Ile-Thr (SEQ ID NO:1) and Arg-Met-Leu-Thr (SEQ ID NO:2), were obtained by elastase enzymatic digestion of IL-2, synthesized and modified. The peptides are useful in conditions of acute and chronic inflammation such as in autoimmune diseases.
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