Inhibitors for de novo-RNA polymerases and methods of identifying targets for same
US6906190B2 · kind B2 · utility
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Key dates
| Filing date | Dec 27, 2002 |
| Grant date | Jun 14, 2005 |
| Priority date | — |
| Expiry date | Feb 9, 2023 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A polymerase inhibitor has first moiety coupled to a second moiety via an optional linker in which the first moiety binds to an initiation nucleotide binding site of a polymerase and forms at least two hydrogen bonds with an RNA template strand that is associated with the polymerase, and in which the second moiety comprised a compound that binds to a site proximal to the nucleotide binding site of the polymerase and thereby increases the affinity of the polymerase inhibitor to the polymerase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.