Plant MSH2 sequences and methods of use
US6906243B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Dec 20, 2001 |
| Grant date | Jun 14, 2005 |
| Priority date | — |
| Expiry date | Dec 29, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/8222
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to isolated nucleic acid molecules encoding MutS homologues (MSHs). Such MSH proteins are involved in DNA mismatch-repair processes in organisms. The invention provides isolated nucleic acid molecules comprising MSH2 nucleotide sequences which encode MSH2 proteins and MSH2 nucleotide sequences which encode dominant-negative MSH2 variants. Such MSH2 nucleotide sequences find use in altering mismatch repair, mutation rates and recombination frequencies in both eukaryotic and prokaryotic organisms. The invention also provides isolated nucleic acid molecules comprising MSH2 promoter nucleotide sequences. Such MSH2 promoter nucleotide sequences find use in regulating the expression of genes of interest in plants. Additionally provided are isolated proteins, transformed host cells, and transformed plants, tissues, cells and seeds thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.