Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade

US6908919B2 · kind B2 · utility

Assignee

• Pharmacia Corporation · SE

Inventors

• Michael S. South · Chesterfield, US
• Brenda Case · Chesterfield, US
• Thomas Dice · Holden, US
• Ricky L. Fenton · Collinsville, US
• Gary W. Franklin · Godfrey, US
• Michael Hayes · Chesterfield, US
• Horng-Chih Huang · Chesterfield, US
• Wei Huang · Wildwood, US
• Darin E. Jones · Ballwin, US
• Carrie Kusturin · Edwardsville, US
• Richard Lindmark · Chesterfield, US
• Scott Long · Holden, US
• William L. Neumann · Chesterfield, US
• David B. Reitz · Chesterfield, US
• John I. Trujillo · Ledyard, US
• Ching-Cheng Wang · New Taipei, TW
• Rhonda Wood · Maryland Heights, US
• Qingping Zeng · Thousand Oaks, US
• Matthew Mahoney · Saint Peters, US
• John J. Parlow · Arnold, US
• Melvin L. Rueppel · Chesterfield, US

Key dates

• Filing date: Jul 15, 2002
• Grant date: Jun 21, 2005
• Expiry date: Aug 30, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.